So I'm like wondering when do I when can I cut the nap out? It's more than that the first time you come along so. But anyways, I had people coming up to me going, I love your podcasts. But he didn't feel comfortable getting it removed there because there was just a bunch of factors that Doc wasn't his doctor, like, you know, all that stuff. The second time he was like vomiting and like, you know, you know, I didn't want to like I had my son was sleeping. It's a game changer. A lot. Not having the EU. They were created when the American pioneers followed the buffalo herds to the Kentucky River, that's when they made it. Interesting. She's a she was she had done her I think her PhD, either her, I don't know, say psychology, but she had done it with a guy I interviewed on the podcast, Dr. Charles Rosen, who is he's the guy who showed that like a single hypothermic treatment, which was with a device that raised the core body temperature like almost three degrees, could have an antidepressant effect. There's zero difference in the benefits of it. Rhonda Patrick Supplements And Lifestyle Tips For Longevity Either I'm getting better shape and I know I am for sure. 20 minutes into it at 210. Well that's me too. I forgot the name of the test, but yeah, that's that's the test. Rhonda has taken many studies into consideration before developing her supplement regimen. The easiest way to send money between your friends and family without having to hold paper cash cash have is also the best way to try to grow your money with their investing feature. I mean those aren't those are Breece Mark Levine at the NIH. You know, it's something because if you if you look at the graph, it's kind of a trans intravenous vitamin C transient. Two hundred milligrams. It's not. It's like, OK, this is this is this is like the morning and your circadian clock starts and then, you know, so you become sleepy when you're supposed to become sleepy, as long as you're not in tons of, you know, bright light at night. Oh, and it's showed there's also studies showing that it decreases the incidence of I'm talking about staphylococcus mutans because it's only when I remember. Dan, Dan had his appendix removed like he so he had was this crazy story. You know, you're not always you just don't succumb to them. @Joe Rogan Experience Dr Rhonda Patrick on the importance of vitamin D Their levels were 50 percent higher over baseline and which is great. I just. So there's studies there's been some large scale and genetic studies that have found that Asians, about 20 percent of Asians have a basically a nucleotide change in a gene that encodes for a protease that's involved in this, you know, basically in allowing this virus to get into the cell. Lots of like there weren't that many females, but there were some from, I don't know, the U.K. or in some German, I don't know. But, yeah, the monoclonal antibodies is a really I know there's like Regeneron, a big company there. I haven't done any research on it, but I just know that I used to take them and I felt like a big effect. Yeah, it's not worth it. Yeah, it was terrible. You make what's called neutralizing antibodies that, you know, basically eventually bind to the virus and neutralize it, prevent it from entering the cell. Better. Yeah. Like, you know, I've just I've got like a bad oral microbiome or something that I've just for four years or I don't know, I shouldn't have cavities because I don't eat sugar. Literally the buffalo on the label is not some neutered buffalo. Legal Zoom's online resources make it easy to get started. It's not going to be forever. What is the one I drink. And when you know the dose and how that's changing your blood levels, like if you're only taking 200 milligrams, which some studies are doing, it's barely doing anything over your baseline, you know. and she has reactive airways. Yeah. Like, it sucks like that. We've, we've been like we have a bunch of elk burger we we ordered online order so on. It's like like three hours before shelter in place was put in California. Wow. So for you personally, if you had the option, would you do it once a week? But there is some actual legitimate research elderberry like has been shown in randomised controlled trials to like effect know the immune system and lower cold duration and stuff like that, you know. So it seems to me the sweet spot you know, and I've been doing it every single day of the quarantine because I have a song in my house. I don't I think that I think what you don't want to just speculate? So I think there's. It's really good. The whole reason I got interested in the sauna was because I was in graduate school doing it like every day. I guess that's the wrong word. Is there any benefit to that? It's all really awful. The medical model used by the United States Endocrine Society covers a wide range of vitamin D functions as opposed to just bones. She suggests the optimal range is a blood concentration between 40 - 60 ng/ml. Yeah. You know, that certainly helps. Yeah. Twenty five minutes on a stationary bike and same things are happening, you know, like blood pressure goes down afterwards, heart rate variability improves, you know, so same things are happening. I'm glad I don't have that. They've endured them all, and they feel a great sense of responsibility to help out when they can. I guarantee you it's going to work because I'm so like the whole time I had a gym membership, it's like unpause. BeWellBuzz. He's at UCSF. It's been used to like help even treat different cardiovascular diseases like it's been shown to improve like current chronic heart failure or something like that. But we handle it like friends. That's awesome. Yeah. And so there's been some studies by the CDC on the on sars-cov-2 where they found basically that people that are infected with SA sars-cov-2 also boost their antibodies against the the common cold one. Just just for the fuck. Well, maybe a Bitcoin cash app is also the easiest way to buy and sell Bitcoin. So there are clinical studies, unfortunately, not a ton of them in the United States that are looking randomized controlled trials, looking at vitamin D, the effects of vitamin D on already, you know, patients with covid-19, which what would be great is like giving them to like first responders or health care workers and seeing like, how does it how does it what what role does it play in prevention? Like multiple studies in humans showing this, it's like a big deal. It's like what happens when you go into menopause. Dr. Rhonda Patrick Vitamin D Dosage & Brand - Brainflow The the really cool thing about and I want to get my mom I think once we move the sauna, like to our home where it's not like the office, like I want to people that are not people that are sedentary and people that are sedentary for whatever reason, maybe they're sedentary because they're disabled or maybe they're sedentary because they've had a lifetime of being sedentary. But yeah, depression is measured. Her podcasts and other videos can be found at FoundMyFitness.com I was like, he tried protein's and I was like talking science. I understand. I mean, I'm always trying to get them to have that. Rhonda Patrick Supplements - What Does She Take? - Drug Genius We wanted to get one here. It's always a treat to have Dr. Rhonda Patrick on. I'm like going around the house, turning well off because, like, I want my son to go to bed at an hour. And then you do that like we did it like three or four times. Kevin Rose tells me I can take my Apple Watch and the hot frickin and do it right. There's a reason why I want to talk about this. And in this I want to call it sciatica. Yeah. Some athletes prefer the ice baths versus cryotherapy, even though it's probably more painful because it lasts a lot longer. You don't you know you don't know them. So the sars-cov-2 one virus does that. It's five. That's awesome. I mean, how so? Look at that graph. We have stocked you up. Or find out how you can speak to an attorney for advice on the right estate plan. And I don't know, I got to, like, do some more reading because, like, it's not that's not uniform. They told me. What's interesting is that the immune system. It's freezing out here in Finland in November. I really hope that. And reading has been shown to be, you know, to increase with exercise and also with heat stress. Wow, that sucks. You make it from UVB, radiation exposure. We're in school work and our office and our cubicle. Right now I'm taking 5000. Right. So I was like staying a nice long as they could, you know, think I'm cool. The average across the globe is 20 ng/ml. Like the sauna to me is like that's so important because it's giving these people a potential cardiovascular workout. So so there are people that have variations in genes that cause them to genetically have lower vitamin D. And so this this is called Mendelian randomisation, where you can take a person that's that has a genetically like it's they're genetically low vitamin D, so you're not categorizing them based on their vitamin D levels. But I mean, I think there's so many things there's just there's so many factors that a lot of data that needs to be passed out for sure. But it does. I must be a little bit on the spectrum because I could swear OP's title doesn't say a damn thing about Rhonda figuring this out. Yeah. So I found that really interesting. Like you want. But for me, it's been a giant game changer. Sometimes you'll hear this EU receptor and that's how the virus gets in, it's like, I don't want that, I want less of that because that's how the virus gets in. Yes. So people that have blood levels higher than 60 may have just a little bit higher calcium level, but not much. That's OK. Yeah, Zink's another one that's really, you know, important for immune function as well. Can you imagine. Showers. Dr. Rhonda Patrick is an American biochemist who has done vast amounts of research on nutrition, supplementation, aging, cancer, and overall health. And there are people with different variations in genes that are related to vitamin D metabolism where they have lower levels and they need a higher dose. And then what's interesting is that like those levels you take, if you take 200, 200 milligrams, it's that doesn't do much. Like they're going to be deficient, you know, and they're so much more like they're like it's wreaking havoc in Sweden on the small population, that is so logical. Bourbon has been designated an essential thing at this time, which I'm all for, that tours at the distillery have been suspended in light of the covid-19 pandemic. Yeah. That's a big difference. So how long he gave me a hat. The way drugs are designed is they like they target a certain molecule and they boom. There is a possibility supplementing with vitamin D can decrease the severity of the COVID-19 infection and eliminate the need for hospitalization. I do I do eventually want to get some kind of like they have those like like those baths that you can like regulate like regulate the water temperature. So there was a study done at the CDC, I don't know, a month ago, maybe a little more, where they measured like they did it. So so I was like, okay, now I'm just like, it's all staphylococcus. But older people have the complete opposite where it's like, you know, deleterious. You do use the sauna, though, right? It was, it was like, OK, now, now we're cooking and I was sweating up a storm. 2015 I stop, I cut that out like I finished my postdoc so I published a couple of studies. I like it a lot. I might see it because when I actually get a chance to watch TV, like it doesn't happen much because right now my son falls asleep at like nine and he wakes up at 6:00. Teeter has two things that are really cool. But, you know, it's like you can't read the comments. Yeah. And I'm like, Laird, I'm doing this thing. It was causing people to have dangerous arrhythmias and stuff. There's like an antioxidant effect in the lungs, like things like that. Unless it's if it's a hundred and ninety or a hundred and eighty eight then I'll do twenty but yeah I do twenty five at one hundred and eighty as well. I forgot the exact number. It's so delicious too. Asymptomatic. Distilled, aged and bottled by Buffalo Trace Distillery 90 Proof. Adding supplements to a healthy diet will most likely not hurt anyone. I love it. Actually, I was doing the sauna too hot at one point in time, I was doing it at 210 degrees because of crazy Laird Laird Hamilton had me convinced. Yes, sure. That was after it, so there was like 30 or so people there and there were from all around the world, there's only like three Americans, Meedan and some other guy I know, four Americans, I think. It's like, OK, this is not my field. Have you ever measured your heart rate during it? You know, I think that potentially, you know, I think it really should be explored. We got we got a lot in the vitamin D information was so fascinating. You're always an awesome resource. Awesome. But I most of the time constantly where it's sometimes because it only it's like the sensor lasts for ten days and have to change it and sometimes I like forget it and a couple of days go by and then I start like eating the pomegranate because my son loves that. We said, OK, yeah, brain drive DNF brain derive nootropic factor. We were in a big I don't know what it was called, but I didn't sleep the whole night and it was awful. And also you can do leg extensions and a bunch of other people doing dips and other exercises from the the teeter. And I totally stopped having for the most part, Dan says, yeah, like I went through one episode where what happens when someone has a nightmare is like if someone else in the sharing the bed with you, like, tries to stop you or help, like because I'm still asleep, I'm not aware that that's my husband doing that. I mean, they're cold and grumpy, I'm sure. But I think it has huge potential, you know. And it's generally safe to take like like four thousand. Yeah, I supplement with it as well. Their actual job is to be around infected people. Like his frequent podcast guest Dr. Rhonda Patrick, Rogan is a big fan of vitamin D3. It's thought the sars-cov-2 also does it because it goes through the same enters through the same receptor. How about that. Maybe it was running, running and cycling. A lot of people have a problem with Seabass. A portal to discuss Joe Rogan, JRE, comedy, cars, MMA, music, food, psychedelics, mind-expanding revelations, conspiracies, insights, and fitness & health. So like flavonoids, like quercetin, quercetin found in like apples, onions, buckwheat teas, which is what I drink. But the nightmare thing, I'm just the melatonin has helped so that's great. So it's micrograms per liter in their blood. But, you know, that's another possibility for sure. It was Nuru. That's so crazy. Randomized controlled trials showing that zinc, zinc acetate or zinc gluconate like lozenges, they can dramatically lower the duration of common cold. Back in 2000, the gang at Buffalo Trace was sipping whiskey and winning Distillery of the Year by Whiskey Advocate magazine. If you would prefer a capsule form of vitamin K2 and vitamin k we suggest . So heat, shock proteins which do like amazing. But but the popcorn. It's like trying to strike up a conversation in a porta potty because it affects me. But, you know, if you're if you're if you're at 210, you can't stay in there for twenty five minutes or twenty minutes. I guess it was non significant for whatever reason. So that's the thing we got to be careful about. And I would get out and I would go out to the mats out there and just collapse. And there's this link between I published a link also between vitamin D and autism. I was like, one day we're all going to die and then the sun's going to explode. And so the type of antibodies were identified. I would take if you just had access to it every day, how often would you take intravenous vitamin C? So like in combination with some of this other stuff, like from days of yore, which is, you know, it's not like a silver bullet, but it seems like it's also promising, promising probably with a combination of other other factors as well. I've seen a guy who wears one of those, but he's diabetic. Yes. So, yes. You know, so that's that's kind of the the reason to kind of be cautious when when you have something new and a small one small study just seems like in the beginning at least, they're trying to figure out what the correct treatment was for these people as they were just showing up in mass in the emergency rooms and they didn't really know. It's been like compared like twenty five minutes in the sauna. Right. So so when you're younger and if you have it, it actually enhances immune function. And I think that that I think that eventually there's going to be therapeutics that are identified, you know, not multiple ones maybe. Podcast Notes is a Signal From the Noise LLC Production, All Right Reserved, Berkshire Hathaway Annual Shareholders Meeting, Christopher Lockhead's Follow Your Different, Everyday Espionage Podcast with Andrew Bustamante, Feel Better, Live More With Dr. Rangan Chatterjee, Moonshots and Mindsets with Peter Diamandis, Network State Podcast with Balaji Srinivasan, Spearhead with Naval Ravikant and Babak Nivi, The Unraveling Podcast with Jocko Willink and Darryl Cooper, This Week in Startups with Jason Calacanis, Where It Happens with Sahil Bloom and Greg Isenberg, Sauna: if you have access use the sauna regularly to improve cardiovascular health and immune functions take a hot bath if you dont have access, Theres a big difference between oral vitamin C and Intravenous vitamin C, You can take vitamin C orally but will need a big dose and it still wont have the same effect; IV once per week if you can, Sleep plays a crucial role in immunity, homeostasis, and regulation of body functions, People are actively working on monoclonal antibodies, Improved therapeutic treatments coming, including more repurposing of drugs that will make things less scary, As you get older your immune system declines, There are lifestyle components of immune system you can be proactive about: exercise, sleep, supplements, nutrition, gut-microbiome health, Besides age, the major regulator of immune function seems to be previous virus exposure, not genetics, At any given point you have antibodies against 10 different viruses but youre not always getting sick, 50-80% of US population has had CMV and most people dont ever know they have had it and show no symptoms, CMV impacts immune function differently depending on when you get it, When youre young, it enhances immune response but for older people its deleterious, Interesting tie-in to COVID-19 because we know older people are more prone to severity, Its likely that theres some cross-immunity happening since SARS-COV-2 viruses is part of beta coronaviruses along with SARS-CoV-1 and MRSA, 15-30% of common colds come from coronaviruses so theres a good hypothesis that potentially one or two of common cold virus antibodies could interact with SARS-CoV-2 and neutralize it, Antibody binds to virus and instead of neutralizing it, changes the configuration so the virus can get into the cell better, This activates the immune system and causes pathology, This results in a higher viral load without antibodies to neutralize, Weve seen it happen with coronaviruses, including SARS-CoV-1 and MRSA, The spike region is where antibodies bind and is also the region the virus uses to get into the cell, Currently seeing two major strain mutations in the spike regions one mutation more prominent in Asia, one mutation more predominant in Europe and North America, Brings to light an interesting genetic link to mutations, Theres a theory that the mutation is causing peoples immune system to become more active and lead to severe COVID-19, Monoclonal antibodies: identify specific antibody that binds to spike protein and manufacture them, Problem is this will offer short lived protection since you are not making your own antibodies as you would with a vaccine, Continuous exploration into repurposing drugs and combination drug treatments, Anecdotally, the majority of people on ventilators die partly because ventilators cause more damage to the lungs and can induce more damage, But its hard to say which came first did the ventilator do the damage or was the damage so severe that the patient needed a ventilator, People with Type O blood seem to be less susceptible to contracting COVID-19, People with Type O blood create Type A antibodies which bind to spike region and neutralize antibody so it cant enter the cell, We saw this in SARS-CoV-1 so maybe same for SARS-CoV-2, Another (unproven) theory: Type O blood people have lower levels of blood factor involved in clotting, Hearing more stories that some prisoners are trying to contract SARS-CoV-2 to get out of jail by spitting in a cup and passing to others, First off, its important to distinguish between asymptomatic and pre-symptomatic, Some people do not have symptoms at the time of testing but develop symptoms later so are actually pre-symptomatic, Its possible that viruses have already gone around that environment so antibodies from those viruses are helping in immunity from SARS-CoV-2, Rhonda was also searching to literature to see whether inmates are vaccinated prior to entering but couldnt find that information, Poor sleep has a huge impact on glucose and spikes and also plays a role in maintaining optimal immune functions, Rhonda takes melatonin to help her sleep, 10 mg/day, Regulating circadian rhythm is crucial for sleep, Rhonda makes sure to have bright light exposure in the morning (e.g., opening curtains, walking outside), and changes the lighting in the house in the evening to red lights, 70% of US population has insufficient Vitamin D levels; 28% are deficient, Body can generate naturally when exposed to sun daily, Obese people in US are also more likely to be vitamin D deficient, Genetic polymorphisms: people that have variations in genes that cause them to have less vitamin D, These people are more likely to die from respiratory infection, African Americans in the US are 28x more deficient in vitamin D than Caucasians, A recent study that looked at COVID-19 patients observed an inverse relationship between vitamin D levels and COVID-19 symptoms: the lower the vitamin D levels, the higher the severity of COVID-19, In Indonesia almost all patients that died from COVID-19 were vitamin D deficient, Melanin blocks ability to produce Vitamin D, In the US and Europe, African Americans and black people are more likely to die from COVID-19, Even when adjusting for SES and lifestyle factors, this was still true so something else must be happening, Tolerable upper intake is 4000 IUs per day but its best to get vitamin D blood test to measure levels, There are clinical studies exploring the role of vitamin D but not many in the US, Rhonda wants to see nurses and first responders take vitamin D to see the role in prevention but those studies are not being done, Joe uses the sauna 7 days/week, 180-degrees for 25 min, Rhonda uses the sauna 5 days/week, 180-degrees for 25 min, Heart rate variability improves, blood pressure goes down, cardiovascular health improves, all-cause mortality decreases, Sauna use also improves immune system and makes you more resilient against infection, Brain-derived neurotropic factors (BDNF) increases with exercise and heat stress (sauna), The positive benefits of physical activity on the cardiovascular system were enhanced when sauna was added, Sauna use increases heat shock proteins which prevent muscle atrophy, neurodegenerative genes, and have anti-depressant effects, People who sat in 160-degree sauna for 30 minutes had a 60% increase in heat shock protein compared to baseline, Large Harvard study being done to assess whether hot yoga increases heat shock protein, Heat shock protein have antiviral activity against influenza A, Regular sauna is heating ambient air which in turn raises core body temperature, Infrared saunas are directly heating body without heating the ambient air for example, in a heating tent or blanket, We know more about the effects of dry sauna, For people who dont have access to sauna, a hot bath is a good modality for heat shock protein, Studies being done to assess whether sauna can have anti-depressant effect on depressed patients, Saunas could also provide an avenue for giving sedentary and disabled people the benefits of physical activity without exercising, Ice baths and cold showers can be comparable to cryotherapy but you have to stay in the cold water longer, Cold shock protein hasnt really been measured in humans, instead whats measured is norepinephrine which has been shown to increase, Cold shock protein and hot shock protein have been shown to improve mood as well, The pharmacokinetics of vitamin C are very different in oral vs IV consumption, Oral vitamin C is good for immune function, etc. It is. Cardiovascular. So the ginger lemon does. I don't even know if it's necessary, honestly, to be honest, because again, it's a therapeutic, you know, treatment. Everybody always told me that they're all sick all the time, that people like their military. I don't know what the characters are now, but I'm doing a small number of characters and I'm just sharing one study. Essentially its taking a blood test every few weeks to see how Vitamin D is impacting your levels positively or negatively and slowly over time working you into a range ~30-50ng. Yeah, right. That's how I felt. I think that that seems like a good compromise. And when he was talking about after the fact, what Michael was talking about was how that is proven to be correct in New York and that some monstrous number, like 80 percent of the people put on ventilators wound up dying, not just New York. So the whole point of that is that they're identifying antibodies that can neutralize the virus and they're going to grow them and manufacture them and give them to people. I mean it's like the food that's highest and is that fermented soybean natto. It totally stops it. Right? I think all of those things play a role. So people love to dismiss things, don't they? But then again, it was a different shower. It also correlates. So, I mean, if you if you get a sample like there's been these series of surveys where they basically that just means they both get get a sample of plasma and look for different antibodies, viral antibodies, and they'll find at any given point a person has like antibodies against 10 different viruses just randomly, you know, so you're you're constantly being exposed to viruses.
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